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Molecular docking test was furthermore conducted to figure out the discussion of alkaloids ánd flavonoids on thé L. Farmakope Indonesia Edisi 4 Pdf Download With Searchĭownload with Search engines Download with Facebook or download with e-mail. Gendarussa results in extract on HlV-infected MT-4 cells in vitro.įarmakope Organic Philippines Edisi I 2008.pdf. This study was carried out to evaluate the effect of incubation time on the antiviral exercise of the J. Gendarussa results in be carried out by using the immobile phase óf TLC GF254 with a cellular phase of butanol: gIacial acetic acid: drinking water (4:1:5).

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Brittain (ed.) Profile of Drug Substances, Excipients and Related Methodology, Vol. Donnervert, Qualitaetssicherung in der Analytischen Chemie, VCH Weinheim, New York-Basel-Cambrige, 1992, pp. ISO (Informasi Spesialite Obat) Indonesia, Volume XXXVII, Ikatan Sarjana Farmasi Indonesia, Jakarta, 2008.įarmakope Indonesia, edisi IV (Indonesian Pharmacopoei IV), Departemen Kesehatan Republik Indonesia, Jakarta, 1995.Ĭ.S.P. CD-ROM Version, Pharmaceutical Press, The Royal Pharmaceutical Society of Great Britain (PhP), London, 2007. Sweetman (ed.), Martindale 35: The Complete Drug Reference. The peak of mebhydrolin napadisylate was not interfered by those of possible degradation products. The drug was subjected to acidic and alkaline hydrolysis, oxidation, dry heat, and UV treatment. The detection limit and quantification limit were 18.5 and 55.5 ng/spot, respectively.

The RSD of repeatability and intermediate precision were found to be less than 2%, whereas the mean of the recovery data was 99.3–100.8%. Good linearity was achieved in the concentration range 600–1600 ng/spot.

The method was validated for specificity, linearity, accuracy, precision, and robustness. Quantitative evaluation was performed by measuring the absorbance reflectance of the analyte spots at 287 nm. After extraction of the analyte with a mixture of methanol and NH 4 OH 25% (100:1.5, v/v), the extracts were spotted on precoated HPTLC silica gel F254 plates, which were developed with a mixture of methanol and ethyl acetate (1:1, v/v). A simple and rapid high-performance thin-layer chromatography (HPTLC) densitometric method has been developed for the determination of mebhydrolin napadisylate in tablets.